by Open Science Repository Pharmaceutics
(December, 2012)
Abstract
Objectives: Studies on the relation between anti-tuberculosis drugs and proteins metabolites are numerous but, on the whole, desultory and inconclusive. The aim of this study was to investigate concentration of urea, creatinine and uric acid in the serum of Sudanese patients with tuberculosis before and after treatment.
Material and methods: A case-control of 200 Sudanese patients with tuberculosis was compared with 50 healthy subjects as control groups. A serum sample was taken and urea, creatinine and uric acid were analyzed using colorimetric methods.
Results: This study indicated that urea levels were significantly higher (P < 0.01) in serum of sputum negative before treatment and sputum positive TB patients after treatment with Streptomycin, Pyrazinamide, Rifampicin and Ethambutol. Serum creatinine was significantly higher (P < 0.01) for the TB patients before and after treatment compared to that of control, with exception of sputum positive patients who received Streptomycin, Pyrazinamide and Rifampicin. Uric acid in serum of sputum negative and sputum positive TB patients before treatment was significantly lower (P < 0.01) relative to that of healthy groups. However, its level was increased slightly after various treatments.
Conclusion: This study suggests an association between anti-tuberculosis drugs and levels of serum urea, creatinine and uric acid.
Keywords: tuberculosis, protein metabolites, anti-tuberculosis drug, Sudanese patients.